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...........Transgenic Technology..........

Over the last decade, the analysis of gene function with the help of genetically altered animals has become more and more important. A better understanding of human diseases such as Alzheimer's disease, diabetes or even cancer is a universal need. Basic research with special animal models is necessary to understand the complexity of these diseases.

For over 10 years, RCC has developed innovative and high-quality animal models for biomedical research and related services. We offer a comprehensive service for the creation of genetically modified mouse models, such as:

 

	microinjection
	embryonic stem (ES) cells
	blastocyst injection
	CreLox system
	SPF derivation
	embryo freezing
	special breeding programmes

A representative, but non-inclusive, list of purposes for which transgenic animals have been used indicates the wide ranging application of this biotechnology:

• in medical research, transgenic animals are used to identify the functions of specific factors in complex homeostatic systems through over- or under-expression of a modified gene (the inserted transgene);
  
• in toxicology: as responsive test animals (detection of toxicants);
  
• in mammalian developmental genetics;
  
• in molecular biology, the analysis of the regulation of gene expression makes use of the evaluation of a specific genetic change at the level of the whole animal;
  
• in the pharmaceutical industry, targeted production of pharmaceutical proteins, drug production and product efficacy testing;
  
• in biotechnology: as producers of specific proteins;
  
• genetically engineered hormones to increase milk yield, meat production; genetic engineering of livestock and in aquaculture affecting modification of animal physiology and/or anatomy; cloning procedures to reproduce specific blood lines; and
  
• developing animals specially created for use in xenografting.

Important general considerations include the extent to which experience acquired in the laboratory with regard to husbandry should influence industry standards for keeping animals created specifically as living machines for the production of proteins, antibodies, etc. What words are appropriate to describe and evaluate the condition of animals now used as production units? The successful cloning of Dolly underlines the fact that innovative developments in animal science are part of the mainstream of biotechnology. In addition, the use of xenografts, at least at the public health level makes animal and human welfare inseparable.